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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals

Fig. 2

LCO particles induce MN in lung epithelial cells in vivo. Wistar rats were treated with an oro-pharyngeal aspiration of NaCl (control, CTL), WC-Co, LCO or LTO particles. Inflammation and MN were assessed after 3 d. LDH activity (a) was measured in the BALF, recruited inflammatory cells (b) in the BAL and the frequency of micronuclei (c) in AT-II cells isolated from rat lungs. Image of an AT-II cell containing a micronucleus designated by the red arrow (c). *P < 0.05, **P < 0.01 and ***P < 0.001 relative to CTL mice (t-test or one-way ANOVA followed by a Dunnett’s multiple comparison). Bars represent means ± SEM (N = 2, n = 4 for the first experiment and n = 2 for the second experiment)

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