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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals

Fig. 5

LCO particles induces MN via •OH generation. Rat lung epithelial cells (RLE, 55556 cells/cm2) were exposed to culture medium (control, CTL), WC-Co, LCO particles in absence (CAT-) or in presence of 3000 U/ml catalase (CAT+). Cytotoxicity was assessed after 24 h by the CellTiter-Glo Luminescence viability test (a). The CBPI (b) was assessed in 500 cells, and the number of MN in 1000 binucleated cells (c). *P < 0.05, **P < 0.01 and ***P < 0.001 (t-test or one-way ANOVA followed by a Dunnett’s multiple comparison relative to the control condition, and t-test between CAT- et CAT+ conditions). Bars represent means ± SEM (N = 2 for cytotoxicity assessment and N = 3 for CPBI and MN assessment, n = 4 for cytotoxicity assessment and n = 2 for CBPI and MN assessment)

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