Table 1 Hematologic and blood chemical parameters of main group rats exposed to benzalkonium chloride

Concentration (mg/m³)

0

0.8

4

20

0

0.8

4

20

 WBC (× 10³/μL)

4.17 ± 0.73

4.56 ± 0.46

3.47 ± 0.72

3.07 ± 0.84

4.42 ± 0.59

4.09 ± 0.54

3.55 ± 0.60

2.50 ± 0.39^b

 RBC (×10⁶/μL)

8.40 ± 0.29

8.68 ± 0.16

8.97 ± 0.13^b

9.56 ± 0.19^b

9.04 ± 0.21

8.82 ± 0.10

9.21 ± 0.15

9.54 ± 0.37

 HCT (%)

43.52 ± 1.27

44.56 ± 1.17

45.42 ± 0.69^a

48.12 ± 1.16^b

45.28 ± 0.59

44.48 ± 0.61

46.12 ± 0.76

47.58 ± 2.35

 Hb (g/dL)

14.50 ± 0.26

14.96 ± 0.21^a

15.42 ± 0.30^b

16.44 ± 0.34^b

15.60 ± 0.24

15.32 ± 0.42

15.86 ± 0.23

16.40 ± 0.67

 MCV (fL)

51.84 ± 1.06

51.30 ± 0.57

50.62 ± 0.59

50.32 ± 0.37^c

50.14 ± 0.67

50.40 ± 0.46

50.06 ± 0.39

49.88 ± 0.51

 MCH (g/dL)

17.28 ± 0.37

17.24 ± 0.15

17.20 ± 0.37

17.22 ± 0.16

17.28 ± 0.28

17.38 ± 0.35

17.20 ± 0.10

17.20 ± 0.07

 MCHC (g/dL)

33.28 ± 0.52

33.62 ± 0.50

33.96 ± 0.49

34.16 ± 0.37^a

34.46 ± 0.25

34.44 ± 0.72

34.36 ± 0.17

34.46 ± 0.39

 RETA (× 10⁹/L)

260.70 ± 41.33

241.48 ± 22.83

190.72 ± 17.52

30.48 ± 2.94^d

186.50 ± 40.82

162.16 ± 28.66

139.66 ± 14.54

137.66 ± 15.18

 RET (%)

3.12 ± 0.58

2.79 ± 0.29

2.12 ± 0.20

0.32 ± 0.03^d

2.07 ± 0.50

1.84 ± 0.33

1.52 ± 0.18

1.44 ± 0.12c

 PLT (×10³/μL)

928 ± 39

892 ± 23

823 ± 43^b

510 ± 39^b

840 ± 49

806 ± 47

844 ± 78

842 ± 73

 LYMA (×10³/μL)

3.22 ± 0.51

3.58 ± 0.41

2.45 ± 0.58

2.23 ± 0.67^a

3.35 ± 0.51

3.22 ± 0.58

2.68 ± 0.64

1.78 ± 0.19^b

 MONA (×10³/μL)

0.08 ± 0.02

0.10 ± 0.01

0.07 ± 0.03

0.07 ± 0.04

0.13 ± 0.03

0.09 ± 0.01

0.09 ± 0.04

0.07 ± 0.02^b

 EOSA (×10³/μL)

0.05 ± 0.01

0.07 ± 0.02

0.08 ± 0.02^a

0.05 ± 0.02

0.06 ± 0.01

0.07 ± 0.03

0.07 ± 0.02

0.06 ± 0.01

 EOS% (%)

1.20 ± 0.27

1.46 ± 0.26

2.34 ± 0.23^a

1.80 ± 0.90

1.40 ± 0.25

1.78 ± 0.90

2.02 ± 0.31

2.38 ± 0.30

 BAS%(%)

0.32 ± 0.05

0.26 ± 0.09

0.18 ± 0.08^a

0.18 ± 0.08^a

0.30 ± 0.14

0.32 ± 0.05

0.22 ± 0.08

0.26 ± 0.18

 APTT (sec)

16.26 ± 0.67

17.10 ± 0.55

18.12 ± 0.66

21.08 ± 1.89^d

17.44 ± 1.46

16.88 ± 0.51

17.78 ± 0.70

19.32 ± 0.92^a

 PT (sec)

11.00 ± 0.38

10.98 ± 0.61

12.04 ± 0.42^a

12.78 ± 0.68^b

11.18 ± 0.37

11.58 ± 0.30

12.64 ± 0.54^b

13.70 ± 0.41^b

 ALT (IU/L)

36.06 ± 3.04

37.28 ± 3.52

35.24 ± 2.64

47.22 ± 11.48^a

30.14 ± 2.59

28.02 ± 3.39

32.34 ± 3.24

36.52 ± 5.64

 ALP (IU/L)

914.28 ± 71.49

896.70 ± 51.47

788.74 ± 45.07^a

675.46 ± 74.70^b

599.54 ± 44.44

592.44 ± 52.97

647.14 ± 21.79

639.04 ± 74.65

 TG (mg/dL)

53.98 ± 20.09

49.26 ± 9.06

27.02 ± 6.12

17.92 ± 1.44^b

16.76 ± 3.52

16.26 ± 5.62

12.88 ± 2.39

16.56 ± 2.96

 CK (U/L)

618.66 ± 142.76

583.08 ± 163.15

545.66 ± 130.72

244.94 ± 41.77^b

242.06 ± 35.26

297.80 ± 148.68

257.30 ± 106.39

212.24 ± 63.77

 Cl (mmol/L)

94.62 ± 0.71

96.32 ± 3.05

95.56 ± 0.20

91.06 ± 2.88

97.62 ± 1.40

97.78 ± 0.61

99.04 ± 0.63

97.32 ± 1.15

 K (mmol/L)

4.52 ± 0.22

4.62 ± 0.13

4.80 ± 0.19

4.64 ± 0.37

4.08 ± 0.16

4.06 ± 0.11

4.32 ± 0.15^a

4.26 ± 0.13

 Na (mmol/L)

134.70 ± 0.49

135.72 ± 2.96

134.98 ± 0.67

136.34 ± 1.176

134.58 ± 0.52

135.22 ± 0.61

136.80 ± 0.83^b

138.10 ± 0.77^b