| Recovery group | |||||||
---|---|---|---|---|---|---|---|---|
Recovery period | 2 Weeks | 4 Weeks | ||||||
Concentration (mg/m3) | 0 | 0.8 | 4 | 20 | 0 | 0.8 | 4 | 20 |
Hematology | ||||||||
 WBC (×103/μL) | 4.65 ± 1.10 | 4.65 ± 0.50 | 4.48 ± 0.92 | 4.64 ± 0.71 | 4.70 ± 0.46 | 5.38 ± 0.69 | 4.45 ± 0.54 | 3.74 ± 1.15 |
 RBC (×106/μL) | 9.02 ± 0.31 | 8.98 ± 0.112 | 8.96 ± 0.27 | 8.95 ± 0.16 | 8.89 ± 0.10 | 9.00 ± 0.19 | 8.89 ± 0.16 | 8.77 ± 0.31 |
 HCT (%) | 43.68 ± 1.37 | 43.40 ± 0.68 | 43.66 ± 0.84 | 44.22 ± 0.93 | 42.16 ± 0.26 | 42.62 ± 0.66 | 42.52 ± 0.44 | 42.78 ± 1.71 |
 Hb (g/dL) | 14.84 ± 0.47 | 14.72 ± 0.30 | 14.72 ± 0.34 | 14.90 ± 0.29 | 14.28 ± 0.24 | 14.46 ± 0.22 | 14.38 ± 0.15 | 14.38 ± 0.50 |
 MCV (fL) | 48.42 ± 0.36 | 48.32 ± 0.36 | 48.80 ± 0.68 | 49.38 ± 0.21b | 47.40 ± 0.39 | 47.32 ± 0.40 | 47.84 ± 0.54 | 48.74 ± 0.55b |
 MCH (g/dL) | 16.4 ± 0.1 | 16.4 ± 0.2 | 16.4 ± 0.2 | 16.7 ± 0.1 | 16.00 ± 0.09 | 16.10 ± 0.11 | 16.10 ± 0.25 | 16.40 ± 0.07b |
 MCHC (g/dL) | 33.91 ± 0.07 | 33.94 ± 0.25 | 33.70 ± 0.30 | 33.74 ± 0.30 | 33.92 ± 0.43 | 33.96 ± 0.13 | 33.78 ± 0.31 | 33.60 ± 0.27 |
 RETA (×109/L) | 250.48 ± 34.86 | 256.74 ± 5.45 | 328.56 ± 47.76b | 319.96 ± 30.79a | 270.34 ± 16.42 | 239.50 ± 18.57 | 280.40 ± 25.11 | 292.90 ± 20.89 |
 RET (%) | 2.78 ± 0.40 | 2.86 ± 0.05 | 3.67 ± 0.58b | 3.58 ± 0.33a | 3.04 ± 0.18 | 2.66 ± 0.25 | 3.15 ± 0.32 | 3.34 ± 0.18 |
 PLT (×103/μL) | 788.0 ± 37.29 | 816.4 ± 11.78 | 871.4 ± 32.55c | 872.2 ± 21.35c | 787 ± 20 | 773 ± 43 | 806 ± 36 | 789 ± 49 |
 LYMA (×103/μL) | 3.23 ± 0.87 | 3.37 ± 0.37 | 3.13 ± 0.84 | 3.29 ± 0.42 | 3.40 ± 0.44 | 3.89 ± 0.27 | 2.89 ± 0.72 | 2.58 ± 0.87 |
 MONA (×103/μL) | 0.12 ± 0.05 | 0.10 ± 0.37 | 0.11 ± 0.03 | 0.13 ± 0.05 | 0.11 ± 0.03 | 0.12 ± 0.02 | 0.12 ± 0.02 | 0.08 ± 0.01 |
 EOSA (×103/μL) | 0.07 ± 0.01 | 0.07 ± 0.01 | 0.06 ± 0.01 | 0.07 ± 0.02 | 0.07 ± 0.03 | 0.08 ± 0.02 | 0.06 ± 0.02 | 0.06 ± 0.01 |
 EOS% (%) | 1.44 ± 0.21 | 1.52 ± 0.26 | 1.28 ± 0.30 | 1.48 ± 0.16 | 1.48 ± 0.48 | 1.48 ± 0.31 | 1.42 ± 0.43 | 1.68 ± 0.31 |
 APTT (sec) | 19.48 ± 2.32 | 18.92 ± 0.66 | 19.12 ± 0.35 | 21.04 ± 3.60 | 16.54 ± 0.68 | 17.22 ± 0.42 | 16.70 ± 0.44 | 16.90 ± 0.57 |
 APT (sec) | 10.28 ± 0.16 | 10.72 ± 0.52 | 9.98 ± 0.11 | 10.24 ± 0.24 | 10.46 ± 0.35 | 10.68 ± 0.26 | 10.38 ± 0.42 | 11.42 ± 0.46b |
Clinical chemistry | ||||||||
 ALT (IU/L) | 49.40 ± 23.18 | 39.28 ± 2.88 | 40.52 ± 1.10 | 42.12 ± 2.80 | 41.40 ± 1.05 | 43.18 ± 1.00 | 42.18 ± 1.25 | 45.02 ± 6.36 |
 ALP (IU/L) | 695.52 ± 28.52 | 688.96 ± 29.80 | 777.70 ± 51.71a | 770.64 ± 54.58a | 594.10 ± 24.24 | 579.14 ± 23.36 | 648.06 ± 40.10 | 680.92 ± 62.32a |
 TG (mg/dL) | 74.30 ± 9.57 | 66.82 ± 12.77 | 74.64 ± 24.61 | 63.28 ± 9.17 | 104.52 ± 25.24 | 84.08 ± 27.14 | 94.68 ± 37.22 | 59.40 ± 18.83 |
 CK (U/L) | 311.82 ± 119.04 | 270.86 ± 127.51 | 298.22 ± 125.41 | 290.66 ± 107.74 | 453.02 ± 114.84 | 400.54 ± 191.10 | 384.44 ± 151.55 | 435.16 ± 225.82 |
 Cl (mmol/L) | 102.48 ± 1.21 | 103.94 ± 0.85 | 104.10 ± 0.88 | 103.24 ± 1.44 | 102.24 ± 1.30 | 103.20 ± 1.39 | 103.96 ± 0.40 | 104.20 ± 0.91a |
 K (mmol/L) | 4.56 ± 0.68 | 4.36 ± 0.53 | 4.34 ± 0.57 | 4.92 ± 1.06 | 4.40 ± 0.46 | 4.52 ± 0.80 | 5.04 ± 0.42 | 4.56 ± 0.80 |
 Na (mmol/L) | 143.74 ± 1.44 | 144.24 ± 0.81 | 144.92 ± 0.41 | 143.92 ± 1.43 | 143.40 ± 0.68 | 143.50 ± 0.62 | 144.34 ± 0.44a | 144.64 ± 0.49b |