Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

Hye-Yeon Choi; Yong-Hoon Lee; Cheol-Hong Lim; Yong-Soon Kim; In-Seop Lee; Ji-Min Jo; Ha-Young Lee; Hyo-Geun Cha; Hee Jong Woo; Dong-Seok Seo

doi:10.1186/s12989-020-0339-8

Table 2 Hematologic and blood chemical parameters of recovery group male rats exposed to benzalkonium chloride

From: Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

	Recovery group
Recovery period	2 Weeks				4 Weeks
Concentration (mg/m³)	0	0.8	4	20	0	0.8	4	20
Hematology
WBC (×10³/μL)	4.65 ± 1.10	4.65 ± 0.50	4.48 ± 0.92	4.64 ± 0.71	4.70 ± 0.46	5.38 ± 0.69	4.45 ± 0.54	3.74 ± 1.15
RBC (×10⁶/μL)	9.02 ± 0.31	8.98 ± 0.112	8.96 ± 0.27	8.95 ± 0.16	8.89 ± 0.10	9.00 ± 0.19	8.89 ± 0.16	8.77 ± 0.31
HCT (%)	43.68 ± 1.37	43.40 ± 0.68	43.66 ± 0.84	44.22 ± 0.93	42.16 ± 0.26	42.62 ± 0.66	42.52 ± 0.44	42.78 ± 1.71
Hb (g/dL)	14.84 ± 0.47	14.72 ± 0.30	14.72 ± 0.34	14.90 ± 0.29	14.28 ± 0.24	14.46 ± 0.22	14.38 ± 0.15	14.38 ± 0.50
MCV (fL)	48.42 ± 0.36	48.32 ± 0.36	48.80 ± 0.68	49.38 ± 0.21^b	47.40 ± 0.39	47.32 ± 0.40	47.84 ± 0.54	48.74 ± 0.55^b
MCH (g/dL)	16.4 ± 0.1	16.4 ± 0.2	16.4 ± 0.2	16.7 ± 0.1	16.00 ± 0.09	16.10 ± 0.11	16.10 ± 0.25	16.40 ± 0.07^b
MCHC (g/dL)	33.91 ± 0.07	33.94 ± 0.25	33.70 ± 0.30	33.74 ± 0.30	33.92 ± 0.43	33.96 ± 0.13	33.78 ± 0.31	33.60 ± 0.27
RETA (×10⁹/L)	250.48 ± 34.86	256.74 ± 5.45	328.56 ± 47.76^b	319.96 ± 30.79^a	270.34 ± 16.42	239.50 ± 18.57	280.40 ± 25.11	292.90 ± 20.89
RET (%)	2.78 ± 0.40	2.86 ± 0.05	3.67 ± 0.58^b	3.58 ± 0.33^a	3.04 ± 0.18	2.66 ± 0.25	3.15 ± 0.32	3.34 ± 0.18
PLT (×10³/μL)	788.0 ± 37.29	816.4 ± 11.78	871.4 ± 32.55^c	872.2 ± 21.35^c	787 ± 20	773 ± 43	806 ± 36	789 ± 49
LYMA (×10³/μL)	3.23 ± 0.87	3.37 ± 0.37	3.13 ± 0.84	3.29 ± 0.42	3.40 ± 0.44	3.89 ± 0.27	2.89 ± 0.72	2.58 ± 0.87
MONA (×10³/μL)	0.12 ± 0.05	0.10 ± 0.37	0.11 ± 0.03	0.13 ± 0.05	0.11 ± 0.03	0.12 ± 0.02	0.12 ± 0.02	0.08 ± 0.01
EOSA (×10³/μL)	0.07 ± 0.01	0.07 ± 0.01	0.06 ± 0.01	0.07 ± 0.02	0.07 ± 0.03	0.08 ± 0.02	0.06 ± 0.02	0.06 ± 0.01
EOS% (%)	1.44 ± 0.21	1.52 ± 0.26	1.28 ± 0.30	1.48 ± 0.16	1.48 ± 0.48	1.48 ± 0.31	1.42 ± 0.43	1.68 ± 0.31
APTT (sec)	19.48 ± 2.32	18.92 ± 0.66	19.12 ± 0.35	21.04 ± 3.60	16.54 ± 0.68	17.22 ± 0.42	16.70 ± 0.44	16.90 ± 0.57
APT (sec)	10.28 ± 0.16	10.72 ± 0.52	9.98 ± 0.11	10.24 ± 0.24	10.46 ± 0.35	10.68 ± 0.26	10.38 ± 0.42	11.42 ± 0.46^b
Clinical chemistry
ALT (IU/L)	49.40 ± 23.18	39.28 ± 2.88	40.52 ± 1.10	42.12 ± 2.80	41.40 ± 1.05	43.18 ± 1.00	42.18 ± 1.25	45.02 ± 6.36
ALP (IU/L)	695.52 ± 28.52	688.96 ± 29.80	777.70 ± 51.71^a	770.64 ± 54.58^a	594.10 ± 24.24	579.14 ± 23.36	648.06 ± 40.10	680.92 ± 62.32^a
TG (mg/dL)	74.30 ± 9.57	66.82 ± 12.77	74.64 ± 24.61	63.28 ± 9.17	104.52 ± 25.24	84.08 ± 27.14	94.68 ± 37.22	59.40 ± 18.83
CK (U/L)	311.82 ± 119.04	270.86 ± 127.51	298.22 ± 125.41	290.66 ± 107.74	453.02 ± 114.84	400.54 ± 191.10	384.44 ± 151.55	435.16 ± 225.82
Cl (mmol/L)	102.48 ± 1.21	103.94 ± 0.85	104.10 ± 0.88	103.24 ± 1.44	102.24 ± 1.30	103.20 ± 1.39	103.96 ± 0.40	104.20 ± 0.91^a
K (mmol/L)	4.56 ± 0.68	4.36 ± 0.53	4.34 ± 0.57	4.92 ± 1.06	4.40 ± 0.46	4.52 ± 0.80	5.04 ± 0.42	4.56 ± 0.80
Na (mmol/L)	143.74 ± 1.44	144.24 ± 0.81	144.92 ± 0.41	143.92 ± 1.43	143.40 ± 0.68	143.50 ± 0.62	144.34 ± 0.44^a	144.64 ± 0.49^b

The values are expressed as mean ± SD (n = 5 males per group)
^aDunnett Test Significant at the 0.05 level, ^bDunnett Test Significant at the 0.01 level
^cDunn Rank Sum Test Significant at the 0.01 level

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