Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

Hye-Yeon Choi; Yong-Hoon Lee; Cheol-Hong Lim; Yong-Soon Kim; In-Seop Lee; Ji-Min Jo; Ha-Young Lee; Hyo-Geun Cha; Hee Jong Woo; Dong-Seok Seo

doi:10.1186/s12989-020-0339-8

Table 3 Absolute and relative organ weights of main group rats exposed to benzalkonium chloride

From: Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

	Main group
Sex	Male				Female
Concentration (mg/m³)	0	0.8	4	20	0	0.8	4	20
Absolute organ weight (g)
Brain	1.767 ± 0.017	1.758 ± 0.041	1.706 ± 0.039^a	1.683 ± 0.030^b	1.668 ± 0.020	1.659 ± 0.056	1.624 ± 0.097	1.630 ± 0.056
Heart	0.646 ± 0.026	0.603 ± 0.054	0.536 ± 0.022	0.467 ± 0.032##	0.474 ± 0.034	0.445 ± 0.010	0.435 ± 0.036	0.422 ± 0.022^a
Lung	0.330 ± 0.031	0.350 ± 0.026	0.349 ± 0.016	0.309 ± 0.022	0.273 ± 0.050	0.286 ± 0.015	0.299 ± 0.016	0.329 ± 0.071
Liver	5.803 ± 0.257	5.282 ± 0.479	4.513 ± 0.476^b	3.369 ± 0.237^b	3.664 ± 0.300	3.493 ± 0.102	3.192 ± 0.274^a	3.082 ± 0.194^b
Spleen	0.457 ± 0.037	0.438 ± 0.034	0.330 ± 0.021^b	0.214 ± 0.026^b	0.329 ± 0.046	0.317 ± 0.023	0.274 ± 0.016^a	0.220 ± 0.010^b
Kidney	1.384 ± 0.074	1.319 ± 0.077	1.180 ± 0.082^b	1.031 ± 0.068^b	0.999 ± 0.068	0.978 ± 0.038	0.926 ± 0.051	0.895 ± 0.066^a
Relative organ weight (%)
Brain	0.934 ± 0.049	0.978 ± 0.078	1.083 ± 0.107	1.383 ± 0.119^b	1.274 ± 0.064	1.309 ± 0.073	1.359 ± 0.054	1.507 ± 0.073^b
Heart	0.342 ± 0.021	0.333 ± 0.009	0.340 ± 0.024	0.382 ± 0.015^b	0.362 ± 0.017	0.351 ± 0.011	0.364 ± 0.016	0.390 ± 0.020^a
Lung	0.175 ± 0.022	0.194 ± 0.010	0.221 ± 0.016^b	0.254 ± 0.020^b	0.208 ± 0.033	0.226 ± 0.009	0.251 ± 0.031	0.304 ± 0.066^b
Liver	3.064 ± 0.091	2.923 ± 0.110	2.841 ± 0.085^b	2.757 ± 0.112^b	2.791 ± 0.011	2.753 ± 0.077	2.667 ± 0.115	2.844 ± 0.084
Spleen	0.241 ± 0.023	0.242 ± 0.009	0.208 ± 0.009^b	0.175 ± 0.014^b	0.250 ± 0.025	0.250 ± 0.016	0.230 ± 0.021	0.204 ± 0.011^b
Kidney	0.732 ± 0.054	0.732 ± 0.049	0.745 ± 0.024	0.843 ± 0.023^b	0.761 ± 0.021	0.771 ± 0.042	0.775 ± 0.050	0.826 ± 0.048

The values are expressed as mean ± SD (n = 5 males and 5 females per group)
^aDunnett Test Significant at the 0.05 level, ^bDunnett Test Significant at the 0.01 level
##Dunn Rank Sum Test Significant at the 0.01 level

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ISSN: 1743-8977

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