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Table 3 Absolute and relative organ weights of main group rats exposed to benzalkonium chloride

From: Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

 

Main group

Sex

Male

Female

Concentration (mg/m3)

0

0.8

4

20

0

0.8

4

20

Absolute organ weight (g)

 Brain

1.767 ± 0.017

1.758 ± 0.041

1.706 ± 0.039a

1.683 ± 0.030b

1.668 ± 0.020

1.659 ± 0.056

1.624 ± 0.097

1.630 ± 0.056

 Heart

0.646 ± 0.026

0.603 ± 0.054

0.536 ± 0.022

0.467 ± 0.032##

0.474 ± 0.034

0.445 ± 0.010

0.435 ± 0.036

0.422 ± 0.022a

 Lung

0.330 ± 0.031

0.350 ± 0.026

0.349 ± 0.016

0.309 ± 0.022

0.273 ± 0.050

0.286 ± 0.015

0.299 ± 0.016

0.329 ± 0.071

 Liver

5.803 ± 0.257

5.282 ± 0.479

4.513 ± 0.476b

3.369 ± 0.237b

3.664 ± 0.300

3.493 ± 0.102

3.192 ± 0.274a

3.082 ± 0.194b

 Spleen

0.457 ± 0.037

0.438 ± 0.034

0.330 ± 0.021b

0.214 ± 0.026b

0.329 ± 0.046

0.317 ± 0.023

0.274 ± 0.016a

0.220 ± 0.010b

 Kidney

1.384 ± 0.074

1.319 ± 0.077

1.180 ± 0.082b

1.031 ± 0.068b

0.999 ± 0.068

0.978 ± 0.038

0.926 ± 0.051

0.895 ± 0.066a

Relative organ weight (%)

 Brain

0.934 ± 0.049

0.978 ± 0.078

1.083 ± 0.107

1.383 ± 0.119b

1.274 ± 0.064

1.309 ± 0.073

1.359 ± 0.054

1.507 ± 0.073b

 Heart

0.342 ± 0.021

0.333 ± 0.009

0.340 ± 0.024

0.382 ± 0.015b

0.362 ± 0.017

0.351 ± 0.011

0.364 ± 0.016

0.390 ± 0.020a

 Lung

0.175 ± 0.022

0.194 ± 0.010

0.221 ± 0.016b

0.254 ± 0.020b

0.208 ± 0.033

0.226 ± 0.009

0.251 ± 0.031

0.304 ± 0.066b

 Liver

3.064 ± 0.091

2.923 ± 0.110

2.841 ± 0.085b

2.757 ± 0.112b

2.791 ± 0.011

2.753 ± 0.077

2.667 ± 0.115

2.844 ± 0.084

 Spleen

0.241 ± 0.023

0.242 ± 0.009

0.208 ± 0.009b

0.175 ± 0.014b

0.250 ± 0.025

0.250 ± 0.016

0.230 ± 0.021

0.204 ± 0.011b

 Kidney

0.732 ± 0.054

0.732 ± 0.049

0.745 ± 0.024

0.843 ± 0.023b

0.761 ± 0.021

0.771 ± 0.042

0.775 ± 0.050

0.826 ± 0.048

  1. The values are expressed as mean ± SD (n = 5 males and 5 females per group)
  2. aDunnett Test Significant at the 0.05 level, bDunnett Test Significant at the 0.01 level
  3. ##Dunn Rank Sum Test Significant at the 0.01 level