Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

Hye-Yeon Choi; Yong-Hoon Lee; Cheol-Hong Lim; Yong-Soon Kim; In-Seop Lee; Ji-Min Jo; Ha-Young Lee; Hyo-Geun Cha; Hee Jong Woo; Dong-Seok Seo

doi:10.1186/s12989-020-0339-8

Table 4 Absolute and relative organ weights of recovery group male rats exposed to benzalkonium chloride

From: Assessment of respiratory and systemic toxicity of Benzalkonium chloride following a 14-day inhalation study in rats

	Recovery group
Recovery period	2 Weeks				4 Weeks
Concentration (mg/m³)	0	0.8	4	20	0	0.8	4	20
Absolute organ weight (g)
Brain	1.751 ± 0.101	1.804 ± 0.053	1.796 ± 0.018	1.695 ± 0.081	1.831 ± 0.061	1.774 ± 0.095	1.815 ± 0.030	1.786 ± 0.100
Heart	0.702 ± 0.076	0.718 ± 0.030	0.700 ± 0.037	0.681 ± 0.032	0.771 ± 0.034	0.743 ± 0.037	0.736 ± 0.061	0.721 ± 0.086
Lung	0.387 ± 0.035	0.424 ± 0.023	0.394 ± 0.035	0.388 ± 0.021	0.430 ± 0.030	0.419 ± 0.030	0.438 ± 0.043	0.416 ± 0.012
Liver	6.765 ± 0.493	6.738 ± 0.403	6.512 ± 0.131	5.847 ± 0.140^b	7.545 ± 0.576	7.225 ± 0.697	6.987 ± 0.605	6.785 ± 0.578
Spleen	0.517 ± 0.031	0.547 ± 0.027	0.534 ± 0.066	0.488 ± 0.024	0.621 ± 0.064	0.582 ± 0.039	0.575 ± 0.058	0.564 ± 0.036
Kidney	1.573 ± 0.101	1.566 ± 0.100	1.538 ± 0.086	1.424 ± 0.059	1.662 ± 0.122	1.625 ± 0.103	1.583 ± 0.067	1.557 ± 0.070
Relative organ weight (%)
Brain	0.772 ± 0.053	0.799 ± 0.030	0.826 ± 0.014	0.871 ± 0.059^b	0.700 ± 0.031	0.707 ± 0.040	0.761 ± 0.021^a	0.761 ± 0.021^a
Heart	0.309 ± 0.025	0.318 ± 0.010	0.322 ± 0.016	0.349 ± 0.010^b	0.295 ± 0.013	0.296 ± 0.014	0.307 ± 0.025	0.307 ± 0.025
Lung	0.171 ± 0.015	0.188 ± 0.016	0.181 ± 0.013	0.199 ± 0.015^a	0.165 ± 0.019	0.167 ± 0.007	0.177 ± 0.006	0.177 ± 0.006
Liver	2.974 ± 0.082	2.981 ± 0.088	2.992 ± 0.045	3.002 ± 0.054	2.878 ± 0.041	2.870 ± 0.139	2.888 ± 0.126	2.889 ± 0.126
Spleen	0.228 ± 0.009	0.242 ± 0.010	0.245 ± 0.025	0.250 ± 0.008	0.237 ± 0.010	0.232 ± 0.009	0.238 ± 0.012	0.240 ± 0.008
Kidney	0.692 ± 0.018	0.693 ± 0.024	0.706 ± 0.030	0.732 ± 0.032	0.656 ± 0.019	0.647 ± 0.020	0.664 ± 0.017	0.664 ± 0.017

The values are expressed as mean ± SD (n = 5 males per group)
^aDunnett Test Significant at the 0.05 level, ^bDunnett Test Significant at the 0.01 level

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