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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Macrophage autophagy protects mice from cerium oxide nanoparticle-induced lung fibrosis

Fig. 4

Atg5+/− mice are protected from alveolar remodeling. Representative lung tissue sections of WT and Atg5+/− mice exposed to Saline or CeO2 NP (5 or 50 μg, observation at 28 days), after HES (Panel a and b for quantification), Sirius red (Panel c and d for quantification), Collagen type I (Panel e and f for quantification), Collagen type III (Panel g and h for quantification), αSMA (Panel i and j for quantification) and TGF-ß (Panel k and l for quantification). Original magnification × 200. Each individual circle represents the mean value obtained from one animal. Empty circle: saline exposure. Grey circle: 5 μg CeO2 NP exposure. Plain circle: 50 μg CeO2 NP exposure. *p < 0.05

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