Table 3 The interaction between TiO2 particles and LPS on mice
Interaction between | Exposure Time of TiO2 | Parameters of | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Intestinal permeability | Tight junction proteins | Villi height/crypt depth ratio | Inflammatory biomarkers | ||||||||
DAO | LPS | D-lactate | ZO-1 | Occludin | Duodenum | Jejunum | Ileum | Serum | Ileum | ||
TiO2 NPs and LPS | 1 month | – | – | – | – | Ant. | Ant. | – | Ant. | IL-1β (Ant.) | – |
3 months | – | – | – | – | – | – | Ant. | Ant. | – | – | |
6 months | – | – | – | – | – | – | – | – | – | – | |
TiO2 MPs and LPS | 1 month | – | – | – | – | – | Ant. | Ant. | – | – | – |
3 months | – | – | – | – | – | Syn. | Syn. | – | – | – | |
6 months | Ant. | – | – | – | – | – | – | – | – | – | |