Fig. 3

Exposure-induced changes of the breathing pattern. Breathing parameters were measured on days 1, 8, 15 and 22 prior to and immediately after the exposure and running or rest session using a double chamber plethysmograph. The exposure-induced changes were determined by calculating the difference between the measured values pre- and post-exposure. If the difference > 0, an exercise-induced increase is identified. If the difference < 0, an exercise-induced decrease was identified, as shown in (a) for the inspiratory time at day 22. b The average exposure-induced changes of the inspiratory time (ΔTi). c The average exposure-induced changes of the expiratory time (ΔTe). d The average exposure-induced changes of the peak inspiratory flow (ΔPIF). e The average exposure-induced changes of the peak expiratory flow (ΔPEF). f The average exposure-induced changes of the minute volume (ΔMV). g The average exposure-induced changes of the breathing frequency (Δf). Data are shown as mean with SD (n = 7–8 mice/group). *p < 0.05, **p < 0.01, ***p < 0.001 (Two-Way ANOVA)