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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Differential effects of intense exercise and pollution on the airways in a murine model

Fig. 4

Baseline lung function and airway hyperreactivity on day 24. Lung function parameters and airway hyperreactivity were assessed at day 24, 24 h after the last exposure and running or rest session, using the FlexiVent system. a Baseline Tiffeneau-index0.1 was calculated as FEV0.1/FVC. (p = 0.0756, Two-Way ANOVA). b Correlation between baseline Tiffeneau-index0.1 and running distance of saline exposed exercised mice (r = 0.5449, p = 0.1293, Pearson correlation). c Correlation between baseline Tiffeneau-index0.1 and running distance of DEP exposed exercised mice (r = − 0.7313, p = 0.0252, Pearson correlation). d The group average dose-response of the airway resistance (Rn) to methacholine (0–20 mg/ml) was measured using a forced oscillation technique (QP3). **p < 0.01 for Sal/NE compared with Sal/E, ***p < 0.001 for Sal/E compared with DEP/E (Two-Way ANOVA). e The group average dose-response of FEV0.1 (%) to methacholine (0–20 mg/ml) was measured using the negative pressure forced expiration (NPFE) manoeuvre. *p < 0.05 DEP/NE compared with DEP/E (Two-Way ANOVA). f The provocative methacholine concentration inducing a 20% decrease in FEV0.1, relative to the baseline FEV0.1, was calculated based on the dose-response curve of FEV0.1 (%), shown in (e). (exercise-effect with ##p = 0.0080, Two-Way ANOVA). Individual data point in figure a and f are shown with mean (n = 7–9 mice per group)

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