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Fig. 2 | Particle and Fibre Toxicology

Fig. 2

From: Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19

Fig. 2

Expression of ACE2 and TMPRSS2 in FSP-1 positive pulmonary fibrosis areas. Double immunofluorescence was performed in continuous lung tissue sections from IPF patients. Representative images show the colocalization of a ACE2 or b TMPRSS2 with fibroblast marker, FSP-1. c ACE2 and TMPRSS2 also co-localize in the same cells. The rectangle frames are magnified on the right upper corners. 40X magnification. Scale bar: 50 μm. ACE2: angiotensin-converting enzyme 2; TMPRSS2: transmembrane serine protease 2; FSP-1: fibroblast-specific protein 1; IPF: idiopathic pulmonary fibrosis

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