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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19

Fig. 4

KC diminished pulmonary fibrosis development and ACE2 and TMPRSS2 exhibition. a Positive Masson’s trichrome staining and b Picro Sirius Red staining symbolize pulmonary fibrosis. c Immunohistochemistry for ACE2 and TMPRSS2. Pulmonary fibrosis and the expression of ACE2 and TMPRSS2 declined in KC knockout mice. d Quantification of pulmonary fibrosis and ACE2 and TMPRSS2 expression are shown as the median value with the interquartile range. 20X magnification. Scale bar: 50 μm. P values were determined by Kruskal-Wallis test as *** p < 0.001 compared with control group. # p < 0.05 compared with bleomycin plus PM group. KC: keratinocyte chemoattractant; ACE2: angiotensin-converting enzyme 2; TMPRSS2: transmembrane serine protease 2; PM: particulate matter; Bleo:Bleomycin; Bleo+PM: Bleomycin+PM. (n = 4 per group)

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