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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19

Fig. 5

Treatment with Reparixin ameliorated PM-enhanced pulmonary fibrosis and diminished ACE2 and TMPRSS2 expression. a Positivities in Masson’s trichrome staining and b Picro Sirus Red staining symbolize pulmonary fibrosis. c Immunohistochemistry for ACE2 and TMPRSS2. Pulmonary fibrosis and the expression of ACE2 and TMPRSS2 declined with Reparixin treatment. d All boxpolts show the quantification of pulmonary fibrosis and ACE2 and TMPRSS2 expression. Data are shown as the median value with the interquartile range. 20X magnification. Scale bar: 50 μm. P values were determined by Kruskal-Wallis test as ** p < 0.01 and *** p < 0.001 and compared with control group. # p < 0.05 compared with bleomycin plus PM group. PM: particulate matter; ACE2: angiotensin-converting enzyme 2; TMPRSS2: transmembrane serine protease 2; Bleo:Bleomycin; Bleo+PM: Bleomycin+PM. (n = 4 per group)

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