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Fig. 12 | Particle and Fibre Toxicology

Fig. 12

From: Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes

Fig. 12

Schematic and potential mechanisms of Nano-Ni-induced dysregulation of tight junction-associated proteins in human epidermal keratinocytes. Exposure of human epidermal keratinocytes to Nano-Ni caused HIF-1α nuclear accumulation, down-regulation of miR-29b, and upregulation of MMP-2 and MMP-9, and finally resulted in dysregulation of tight junction-associated proteins. Our results demonstrate that Nano-Ni-induced dysregulation of tight junction-associated proteins in skin keratinocytes is via HIF-1α/miR-29b/MMPs pathway

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