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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes

Fig. 4

Dose- and time-dependent induction of TIMP-1 and TIMP-2 mRNAs in HaCaT cells exposed to Nano-Ni. Expression of TIMP-1 and TIMP-2 mRNAs in HaCaT cells were determined by real-time PCR after cells were exposed to 10 or 20 μg/mL of Nano-Ni or Nano-TiO2 for 24 h (a & c), or 20 μg/mL of Nano-Ni for 12, 24, 48, or 72 h (b & d). Cells without treatment were used as control. Data represent mean ± SE (n = 3). * Significant difference as compared with the control group, p < 0.05; # Significant difference as compared with the same dose of Nano-TiO2-treated group, p < 0.05

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