TY - JOUR AU - Liu, Hong AU - Li, Jianyu AU - Ma, Qianli AU - Tang, Jinglong AU - Jiang, Menghui AU - Cao, Xue AU - Lin, Li AU - Kong, Nan AU - Yu, Shanfa AU - Sood, Akshay AU - Zheng, Yuxin AU - Leng, Shuguang AU - Han, Wei PY - 2021 DA - 2021/03/25 TI - Chronic exposure to diesel exhaust may cause small airway wall thickening without lumen narrowing: a quantitative computerized tomography study in Chinese diesel engine testers JO - Particle and Fibre Toxicology SP - 14 VL - 18 IS - 1 AB - Diesel exhaust (DE) is a major source of ultrafine particulate matters (PM) in ambient air and contaminates many occupational settings. Airway remodeling assessed using computerized tomography (CT) correlates well with spirometry in patients with obstructive lung diseases. Structural changes of small airways caused by chronic DE exposure is unknown. Wall and lumen areas of 6th and 9th generations of four candidate airways were quantified using end-inhalation CT scans in 78 diesel engine testers (DET) and 76 non-DETs. Carbon content in airway macrophage (CCAM) in sputum was quantified to assess the dose-response relationship. SN - 1743-8977 UR - https://doi.org/10.1186/s12989-021-00406-1 DO - 10.1186/s12989-021-00406-1 ID - Liu2021 ER -