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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study

Fig. 5

Mean plasma t-PA antigen concentrations after exposure to petrodiesel vs. RME 30 (upper left panel) and petrodiesel vs. RME100 (lower left panel) were not significantly different between exposures (p = 0.73 and p = 0.22, respectively). Stimulated release of t-PA plasma antigen concentrations following incremental doses of bradykinin infusions, expressed as nanogram per 100 mL tissue per minute, mean with 95% CI (upper and lower right panels). Bradykinin infusions caused dose dependent increases in t-PA antigen concentrations that were significant at p < 0.01 level for all exposures; petrodiesel and RME 30 (upper right panel) as well as petrodiesel and RME 100 (lower right panel) by 2-way ANOVA. The bradykinin stimulated increases in t-PA did not differ between petrodiesel or RME exposures (p = 0.43 and p = 0.35, respectively).

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