In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT

Table 1 Physicochemical properties of the NMs included in this study

Nanomaterial	Length nm	Diameter nm	BET m²/g	OH mmol/g	A549 Z-average F12 (nm)	A549 Effective dose⁵	A549 Percent of administered dose (%)	THP-1a Z-average RPMI (nm)	THP-1a Effective dose^e	THP-1a Percent of administered dose (%)
NRCWE-040^a	519	22	150	0.35	199 ± 23	74	46	266 ± 26	42	52
NRCWE-041^a	1005	27	152	1.69	215 ± 15	85	53	283 ± 27	46	57
NRCWE-42^a	723	30	141	4.09	178 ± 10	40	25	276 ± 14	30	37
NRCWE-006^b	5730	74	26	0.08	631 ± 183	40	25	917 ± 80	17	21
NM-400^b,d	847	11	254	0.79	307 ± 94	42	26	223 ± 60	29	36
NM-401^b,d	4048	67	18	0.03	760 ± 122	74	46	978 ± 74	31	39
NM-403^b	443	12	135	0.19	245 ± 39	54	34	285 ± 25	36	45
Printex 90^c	–	14	338	–	125 ± 4	40	25	168 ± 3	38	47

The nanomaterials were previously characterized. Data are extracted from ^aPoulsen et al. 2016, ^bJackson et al., 2015 and ^cJacobsen et al., 2008. ^dThe hydrodynamic diameter of NM-400 and NM-401 dispersed in MilliQ-Water for cell exposure in ALI system was 205 ± 7 and 701 ± 11 nm, respectively. ^e Effective dose quantified by TGA-MS after 24 h incubation as described in Methods. – Not detected

ISSN: 1743-8977