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Table 1 The mice experimental design

From: Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis

Experiment Group No. PS50 (mg/kg body weight) PS500 (mg/kg body weight) PS5000 (mg/kg body weight) Male
(n)
Female
(n)
Biodistribution experimenta) 1 0 0 0 10 5
2 250 (RF) 0 0 10 5
3 250 (RF) 125 (GF) 0 10 5
4 250 (RF) 250 (GF) 0 10 5
5 250 (RF) 500 (GF) 0 10 5
6 0 250 (RF) 0 10 5
7 125 (RF) 250 (GF) 0 10 5
8 500 (RF) 250 (GF) 0 10 5
9 0 0 250 (RF) 10 5
10 250 (RF) 0 250 (GF) 10 5
11 0 250 (RF) 250 (GF) 10 5
Toxicity effects on intestinal barrier experimentb) 1 0 0 0 10 0
2 250 (NF) 0 0 10 0
3 500 (NF) 0 0 10 0
4 0 250 (NF) 0 10 0
5 0 500 (NF) 0 10 0
6 250 (NF) 250 (NF) 0 10 0
Oxidant and antioxidant treatment experimentc) 1 0 0 0 25 0
2 250 (NF) 0 0 15 0
3 500 (NF) 0 0 15 0
4 0 250 (NF) 0 15 0
5 0 500 (NF) 0 15 0
6 250 (NF) 250 (NF) 0 15 0
28-day repeated dose oral toxicity studyd) 1 0 0 0 10 0
2 2.5 (NF) 0 0 10 0
3 25 (NF) 0 0 10 0
4 50 (NF) 0 0 10 0
5 250 (NF) 0 0 10 0
6 500 (NF) 0 0 10 0
7 0 2.5 (NF) 0 10 0
8 0 25 (NF) 0 10 0
9 0 50 (NF) 0 10 0
10 0 250 (NF) 0 10 0
11 0 500 (NF) 0 10 0
12 25 (NF) 25 (NF) 0 10 0
13 250 (NF) 250 (NF) 0 10 0
  1. a) Results in Fig. 3 and 4 and Figures S2, S3, S4, S5, S6, S7, and S8; b) Results in Fig. 5 and Figure S9; c) Results in Fig. 6 and Figures S10 and S11; d) Results in Fig. 7 and Figures S12 and S13. NF, non-fluorescence; RF, red fluorescence; GF, green fluorescence