Fig. 5
Proposed molecular mechanisms associated with lung injury under subchronic and chronic exposures to traffic-related GAS and PM1. Boxes in the upper side of the protein gene symbol indicate the protein expression in PM1 (upper) and GAS (lower) groups. Boxes in the left panel of the upper side show the protein ratios of 3 M-PM1/CTL and 3 M-GAS/CTL, whereas those in the right panel represent progression from 3- to 6-month exposures (PM1-6 M/3 M and GAS-6 M/3 M, respectively). The particle specific regulations are shown as boxes in the right side of the protein gene symbol (3 M-PM1/GAS, 6 M-PM1/GAS, respectively). Upregulated proteins are marked in red, downregulated proteins in green, and unchanged proteins in white. Protein expression enhanced by particles (PM1/GAS) is marked in fuchsia, whereas suppression is marked in cyan