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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Fig. 7

Representative TEM images of capillaries in the hippocampus of mice at the end of treatment. A-B control mouse; C-D AgNP 1 mg/kg bw-treated mouse; E-F AgAc-treated mouse. A Normal capillary and astrocytic perivascular end-feet (asterisk) from a control mouse; B higher magnification of the area highlighted in A showing a portion of normal blood-brain barrier (BBB) with basement membrane (black arrows), and astrocytic perivascular end-feet (asterisk). Swelling of astrocytic perivascular end-feet (asterisk) was observed in AgNP 1 mg/kg bw- (C-D) and AgAc- (E-F) treated mice. Splitting of capillary basement membrane in three and two different branches (black arrows) visible at higher magnification of the BBB, respectively in AgNP 1 mg/kg bw- (D) and AgAc- (F) treated mice. Scale bar = 1µm in panel A, C, E; scale bar = 300 nm in panel B, D, F

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Particle and Fibre Toxicology

ISSN: 1743-8977

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