Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Table 2 Body weight, body weight gain, and organ weight at the end of treatment (EoT) and recovery (Rec) period (n = 6). Data are expressed as mean value ± SD

Time point	Group	Body weight at sacrifice (g)	Body weight gain at sacrifice (%)	Liver (g)	Spleen (g)	Kidneys (g)
EoT	Control (vehicle)	35.58 ± 2.73	21.19 ± 6.19	2.50 ± 0.30	0.12 ± 0.05	0.66 ± 0.07
	AgNP 0.25 mg/kg bw^a	37.41 ± 2.28	30.76 ± 9.74	2.45 ± 0.30	0.12 ± 0.06	0.70 ± 0.07
	AgNP 1 mg/kg bw^a	35.93 ± 3.22	28.96 ± 6.,86	2.50 ± 0.29	0.10 ± 0.01	0.69 ± 0.07
	AgAc 1.55 mg/kg bw	36.15 ± 1.60	21.24 ± 9.94	2.42 ± 0.31	0.12 ± 0.,03	0.66 ± 0.08
Rec	Control (vehicle)	42.60 ± 3.33	47.2 ± 5.80	2.15 ± 0.30	0.10 ± 0.01	0.71 ± 0.05
	AgNP 0.25 mg/kg bw^a	42.62 ± 2.04	52.87 ± 9.89	2.24 ± 0.21	0.12 ± 0.02	0.71 ± 0.07
	AgNP 1 mg/kg bw^a	41.27 ± 2.08	47.30 ± 7.29	2.48 ± 0.20	0.11 ± 0.01	0.73 ± 0.05
	AgAc 1.55 mg/kg bw^b	40.12 ± 4.23	43.83 ± 14.12	2.25 ± 0.33	0.13 ± 0.05	0.69 ± 0.06

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