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Table 3 Hematological values at the end of treatment (EoT) and the recovery (Rec) period (n = 6). Data are expressed as mean value ± SD

From: Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Time point Group WBC x RBC x Hb Ht MCV MCH MCHC Plt x Neutr x Lymph x Mono x Eos x
103/μL 106/μL g/dL % fL pg % 103/μL 103/μL 103/μL 103/μL 103/μL
EoT Control (vehicle) 8.78 ± 1.73 8.13 ± 0.78 11.27 ± 1.14 44.85 ± 2.97 55.27 ± 2.24 13.85 ± 0.29 25.05 ± 1.04 1586.50 ± 318.02 1.15 ± 0.61 7.34 ± 1.41 0.27 ± 0.14 0.03 ± 0.05
AgNP 0.25 mg/kg bw1 8.32 ± 1.59 8.40 ± 0.37 11.52 ± 0.46 46.23 ± 2.42 54.92 ± 0.80 13.68 ± 0.08 24.93 ± 0.34 1448.17 ± 605.28 1.19 ± 0.38 6.40 ± 0.88 0.58 ± 0.54 0.15 ± 0.24
AgNP 1.00 mg/kg bw1 10.05 ± 2.93 8.77 ± 0.32 12.22 ± 0.52 48.93 ± 2.06 55.65 ± 1.33 13.88 ± 0.42 24.98 ± 0.36 1480.00 ± 305.90 0.89 ± 0.35 8.76 ± 2.97 0.33 ± 0.23 0.08 ± 0.11
AgAc 1.55 mg/kg bw2 9.33 ± 2.59 8.23 ± 0.65 11.65 ± 0.87 46.63 ± 3.31 56.63 ± 1.35 14.17 ± 0.24a 25.00 ± 0.20 1409.50 ± 360.08 1.90 ± 2.53 6.76 ± 3.11 0.54 ± 0.47 0.15 ± 0.13
Rec Control (vehicle) 10.48 ± 1.99 8.55 ± 0.48 12.07 ± 0.88 48.60 ± 3.24 56.87 ± 1.18 14.12 ± 0.35 24.82 ± 0.66 1390.67 ± 392.04 1.15 ± 0.53 8.67 ± 1.36 0.58 ± 0.31 0.09 ± 0.11
  AgNP 0.25 mg/kg bw1 7.98 ± 1.56 a 8.83 ± 0.60 12.47 ± 0.73 50.93 ± 2.58 57.70 ± 1.74 14.10 ± 0.50 24.47 ± 0.39 999.33 ± 209.96 1.04 ± 0.24 6.48 ± 1.48 a 0.44 ± 0.21 0.05 ± 0.06
  AgNP 1.00 mg/kg bw1 6.80 ± 2.55*/ a 8.12 ± 0.53 11.58 ± 0.56 47.23 ± 2.29 58.25 ± 2.71 14.28 ± 0.48 24.53 ± 0.87 1069.17 ± 379.94 1.16 ± 0.33 5.17 ± 2.26*/a 0.42 ± 0.31 0.06 ± 0.09
AgAc 1.55 mg/kg bw2 8.50 ± 4.82 9.08 ± 0.39 12.62 ± 0.37 50.77 ± 1.33 56.03 ± 1.25 13.93 ± 0.41 24.85 ± 0.29 933.33 ± 155.88 2.05 ± 1.75 5.82 ± 2.85 a 0.57 ± 0.52 0.06 ± 0.09
  1. 1 Nominal dose (actual delivered doses were 0.20 and 0.80 mg/kg bw)
  2. 2Containing the equivalent dose of 1 mg Ag/kg bwStatistical significance: * = p < 0.05; vs Control (Kruskal-Wallis test, followed by Dunn’s multiple comparison test); a = p < 0.05 vs Control (Mann-Whitney U test)