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Table 3 Hematological values at the end of treatment (EoT) and the recovery (Rec) period (n = 6). Data are expressed as mean value ± SD

From: Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Time point

Group

WBC x

RBC x

Hb

Ht

MCV

MCH

MCHC

Plt x

Neutr x

Lymph x

Mono x

Eos x

103/μL

106/μL

g/dL

%

fL

pg

%

103/μL

103/μL

103/μL

103/μL

103/μL

EoT

Control (vehicle)

8.78 ± 1.73

8.13 ± 0.78

11.27 ± 1.14

44.85 ± 2.97

55.27 ± 2.24

13.85 ± 0.29

25.05 ± 1.04

1586.50 ± 318.02

1.15 ± 0.61

7.34 ± 1.41

0.27 ± 0.14

0.03 ± 0.05

AgNP 0.25 mg/kg bw1

8.32 ± 1.59

8.40 ± 0.37

11.52 ± 0.46

46.23 ± 2.42

54.92 ± 0.80

13.68 ± 0.08

24.93 ± 0.34

1448.17 ± 605.28

1.19 ± 0.38

6.40 ± 0.88

0.58 ± 0.54

0.15 ± 0.24

AgNP 1.00 mg/kg bw1

10.05 ± 2.93

8.77 ± 0.32

12.22 ± 0.52

48.93 ± 2.06

55.65 ± 1.33

13.88 ± 0.42

24.98 ± 0.36

1480.00 ± 305.90

0.89 ± 0.35

8.76 ± 2.97

0.33 ± 0.23

0.08 ± 0.11

AgAc 1.55 mg/kg bw2

9.33 ± 2.59

8.23 ± 0.65

11.65 ± 0.87

46.63 ± 3.31

56.63 ± 1.35

14.17 ± 0.24a

25.00 ± 0.20

1409.50 ± 360.08

1.90 ± 2.53

6.76 ± 3.11

0.54 ± 0.47

0.15 ± 0.13

Rec

Control (vehicle)

10.48 ± 1.99

8.55 ± 0.48

12.07 ± 0.88

48.60 ± 3.24

56.87 ± 1.18

14.12 ± 0.35

24.82 ± 0.66

1390.67 ± 392.04

1.15 ± 0.53

8.67 ± 1.36

0.58 ± 0.31

0.09 ± 0.11

 

AgNP 0.25 mg/kg bw1

7.98 ± 1.56 a

8.83 ± 0.60

12.47 ± 0.73

50.93 ± 2.58

57.70 ± 1.74

14.10 ± 0.50

24.47 ± 0.39

999.33 ± 209.96

1.04 ± 0.24

6.48 ± 1.48 a

0.44 ± 0.21

0.05 ± 0.06

 

AgNP 1.00 mg/kg bw1

6.80 ± 2.55*/ a

8.12 ± 0.53

11.58 ± 0.56

47.23 ± 2.29

58.25 ± 2.71

14.28 ± 0.48

24.53 ± 0.87

1069.17 ± 379.94

1.16 ± 0.33

5.17 ± 2.26*/a

0.42 ± 0.31

0.06 ± 0.09

–

AgAc 1.55 mg/kg bw2

8.50 ± 4.82

9.08 ± 0.39

12.62 ± 0.37

50.77 ± 1.33

56.03 ± 1.25

13.93 ± 0.41

24.85 ± 0.29

933.33 ± 155.88

2.05 ± 1.75

5.82 ± 2.85 a

0.57 ± 0.52

0.06 ± 0.09

  1. 1 Nominal dose (actual delivered doses were 0.20 and 0.80 mg/kg bw)
  2. 2Containing the equivalent dose of 1 mg Ag/kg bwStatistical significance: * = p < 0.05; vs Control (Kruskal-Wallis test, followed by Dunn’s multiple comparison test); a = p < 0.05 vs Control (Mann-Whitney U test)