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Table 4 Serum chemistry values at the end of treatment (EoT) and the recovery (Rec) period (n = 6). Data are expressed as mean value ± SD

From: Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system

Time point Group GLDH Urea Creatinine Triglycerides ALT Albumin Total protein
(U/L) (mg/dL) (mg/dL) (mg/dL) (U/L) (mg/dL) (mg/dL)
EoT Control (vehicle) 8.00 ± 3.51 39.33 ± 3.14 0.32 ± 0.03 154.83 ± 48.40 37.17 ± 28.25 2.31 ± 0.24 5.27 ± 0.79
AgNP 0.25 mg/kg bw1 4.52 ± 2.41a 33.83 ± 4.92 a 0.28 ± 0.01 a 93.50 ± 35.49 a 18.17 ± 6.31 2.40 ± 0.22 4.60 ± 0.29
AgNP 1.00 mg/kg bw1 11.28 ± 3.75 43.83 ± 5.00 0.35 ± 0.11 157.33 ± 36.19 17.83 ± 5.38 2.45 ± 0.29 5.34 ± 0.42
AgAc 1.55 mg/kg bw2 13.32 ± 11.51 34.83 ± 4.02 0.30 ± 0.04 126.50 ± 100.74 24.33 ± 22.72 2.30 ± 0.16 4.54 ± 0.47
Rec Control (vehicle) 25.25 ± 12.92 35.83 ± 3.76 0.34 ± 0.02 171.67 ± 105.08 91.83 ± 88.37 2.12 ± 0.14 5.08 ± 0.91
AgNP 0.25 mg/kg bw1 21.13 ± 6.99 45.00 ± 4.56b 0.37 ± 0.04 233.00 ± 49.78 64.33 ± 52.47 2.43 ± 0.18 b 5.76 ± 0.83
AgNP 1.00 mg/kg bw1 38.62 ± 22.59 47.50 ± 6.38**/b 0.34 ± 0.06 375.33 ± 124.53**/b 322.50 ± 267.38 2.34 ± 0.55 5.12 ± 0.35
AgAc 1.55 mg/kg bw2 17.42 ± 5.71 51.83 ± 6.24***/b 0.34 ± 0.02 214.33 ± 66.45 99.50 ± 83.54 1.36 ± 0.21 b 4.92 ± 0.46
  1. 1 Nominal dose (actual delivered doses were 0.20 and 0.80 mg/kg bw)
  2. 2Containing the equivalent dose of 1 mg Ag/kg bw
  3. Statistical significance: ** = p < 0.01; ***p < 0.001 vs Control (Kruskal-Wallis test, followed by Dunn’s multiple comparison test); a = p < 0.05; b = p < 0.01 vs Control (Mann-Whitney U test)