Fig. 5

MWCNT-induced effect on neutrophil influx depends on the retained surface area dose (measured or estimated) following 1-week (triangle), 2-week (diamond), 4-week (square) or 13-week (circle) inhalation exposure. Details of the post-exposure times are provided in Supplemental 10. Open symbols indicate that the retained surface area dose was estimated using the MPPD model. The retained surface “carbon” dose applied for micronized Baytubes was calculated based on Co analysis (0.53% w/w in pristine MWCNT). The black and purples lines show the regression model fits for MWNT-7 exposure (all durations) and 13-week exposure to micronized Baytubes, respectively. The dotted black and purples lines delimit the 95% confidence intervals of the corresponding regression models