Material | Target concentration (mg/m3) | Post-exposure time | n = | Retained amount measured (mg / g lung) | Retained surface (cm2 / g lung) | Neutrophils (%)c |
---|---|---|---|---|---|---|
P25 | 15 | D3 W4 W26 | 6 6 6 | 3.809 ± 0.641 3.272 ± 1.144 1.328 ± 0.873 | 2095 ± 327 1800 ± 629 730 ± 480 | 40.9 ± 7.0 57.7 ± 8.8 19.9 ± 12.7 |
15 (2-week) | D3 | 10 | 1.699 ± 0.241 | 935 ± 123 | 22.0 ± 8.7 | |
5a | D3 W4 W26 | 6 6 6 | 1.368 ± 0.177 1.386 ± 0.384 0.756 ± 0.429 | 752 ± 90 762 ± 211 416 ± 236 | 13.5 ± 4.9 12.4 ± 7.5 1.7 ± 1.3 | |
5a (2-week) | D3 | 10 | 0.672 ± 0.127 | 370 ± 65 | 5.1 ± 4.0 | |
1.5a | D3 W4 W26 | 6 6 6 | 0.511 ± 0.125 0.296 ± 0.041 0.097 ± 0.074 | 281 ± 64 163 ± 23 54 ± 41 | 2.7 ± 2.9 2.5 ± 0.6 2.2 ± 2.6 | |
1.5a (2-week) | D3 | 10 | 0.246 ± 0.060 | 135 ± 31 | 2.3 ± 2.6 | |
P25 | 5b | D0 D3 W4 W13 W26 | 6 6 6 6 6 | 1.372 ± 0.105 1.286 ± 0.152 0.585 ± 0.055 0.258 ± 0.036 0.122 ± 0.008 | 700 ± 54 656 ± 78 298 ± 28 132 ± 18 62 ± 4 | 4.4 ± 0.9 8.1 ± 2.4 1.2 ± 0.5 1.0 ± 0.6 1.8 ± 0.7 |
Printex-90 | 50 | D3 W4 W26 | 6 6 6 | 2.467 ± 0.131 2.950 ± 0.492 3.708 ± 0.631 | 7797 ± 414 9322 ± 1555 11,717 ± 1994 | 72.9 ± 5.6 52.3 ± 7.4 48.3 ± 6.4 |
15a | D3 W4 W26 | 6 6 6 | 1.340 ± 0.269 1.418 ± 0.234 1.080 ± 0.177 | 4234 ± 850 4481 ± 739 3413 ± 559 | 55.1 ± 19.0 41.0 ± 10.0 9.5 ± 6.0 | |
5a | D3 W4 W26 | 6 6 6 | 0.895 ± 0.228 1.428 ± 0.372 0.553 ± 0.161 | 2827 ± 721 4512 ± 1176 1747 ± 509 | 18.8 ± 4.2 5.2 ± 1.8 2.2 ± 2.3 | |
MWNT-7 | 1.5 | D3 W4 W26 | 6 6 6 | 0.834 ± 0.460 0.310 ± 0.181 < 0.060 | 192 ± 106 71 ± 42 < 14 | 44.7 ± 9.9 28.3 ± 8.9 10.1 ± 5.3 |
0.5a | D3 W4 W26 | 6 6 6 | 0.397 ± 0.217 < 0.060 < 0.060 | 91 ± 50 < 14 < 14 | 30.6 ± 13.5 9.0 ± 4.4 8.3 ± 8.6 | |
0.15a | D3 W4 W26 | 6 6 6 | < 0.060 < 0.060 < 0.060 | < 14 < 14 < 14 | 10.2 ± 8.1 4.9 ± 6.5 4.7 ± 5.3 |