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Table 4 Exposure conditions, curves fitting parameters and onset surface area doses leading to 6% neutrophil infiltration for the different classes of NM studied

From: Retained particle surface area dose drives inflammation in rat lungs following acute, subacute, and subchronic inhalation of nanomaterials

Material Exposure Reference Number of conditionsa Hill equation parametersb Onset surface
area dose
(cm2/g lung)
for 6% neutrophilsc
EC50d Hill sloped R2
P25 2- & 4-week This work
+ [35, 36, 52]
25 1097
[973–1220]
2.98
[1.89–4.09]
0.79 430
P25 13-week [53] 5 4683
[4109–5256]
5.86
[0.98–10.7]
0.91 2904
P25 1-week [54, 55] 7 418
[285–552]
2.88
[0.89–4.87]
0.93 158
Fine TiO2 All duration [54,55,56,57,58,59] 25 2069
[1990–2148]
7.34
[5.36–9.32]
0.99 1413
Printex-90 4-week This work 9 5262
[2795–7728]
2.22
[−0.34–4.78]
0.55 1492
Printex-90 13-week [60, 61] 9 10,038
[6348–13,728]
1.37
[0.50–2.24]
0.88 1301
MWNT-7 2-, 4- & 13-week This work
+ [45, 66]
22 61.6
[47.6–75.5]
1.08
[0.82–1.34]
0.81 4.6
+ NM401, NM402,
NM403, Nanocyl NC7000
All duration + [14, 47, 71, 73] + 32 90.1
[58.9–121.4]
0.85
[0.62–1.09]
0.77 3.3
Micronized Baytubes 13-week   16 6366
[2407–10,326]
0.72
[0.49–0.95]
0.87 130
  1. aconsidered for modelling; conditions means the combinaison of experimental conditions (aerosol, concentration, post-exposure time point, …)
  2. blow and high asymptotic %neutrophils values are “in controls” = 1.8% and “max” = 75%, respectively (see § Model fitting)
  3. c6 = 3 × SD(%neutro in controls)
  4. dThe values in brackets define the asymptotic 95% confidence intervals