Fig. 5
From: Silica-coated magnetic nanoparticles activate microglia and induce neurotoxic d-serine secretion
Ubiquitinated proteins and inclusion bodies accumulate in MNPs@SiO2(RITC)-treated microglia-cocultured neurons. a Immunoblotting analysis of ubiquitinated proteins in the MNPs@SiO2(RITC)-treated microglia-cocultured neurons. b Inclusion body formation in MNPs@SiO2(RITC)-treated microglia-cocultured cortical neurons. Ubiquitin (green), α-synuclein (red), and nucleus (blue) were immunostained. Scale bar = 10 μm. c Quantification (%) of cells with inclusion bodies. *p < 0.05 vs. non-treated control