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Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation

Fig. 3

MWCNT-mediated lung inflammation. Bronchoalveolar lavage fluid (BALF) total protein and infiltrating inflammatory cell count. MWCNT exposure-induced pulmonary inflammation was not altered by MMP blockade. a Total lavage fluid protein concentration assessed via Bradford protein assay. MWCNT-exposure increased BALF total protein in a dose-dependent manner when compared with controls. b and c BALF cell differentials; Polymorphonuclear neutrophils (PMN) cells were significantly increased by MWCNT exposure at both low and high doses; Macrophages in BALF were decreased in MWCNT treated cells. d Total BALF cells were unchanged by MWCNT exposure. p values based on 2-way ANOVA presented for each figure. N = 4–5 per group. Data presented are means ± SEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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