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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation

Fig. 7

MWCNT in vitro serum bioactivity evaluation. Contribution of CD36 to MWCNT-mediated serum cumulative inflammatory potential in mouse cerebrovascular endothelial cells (mCEC). Cells in monolayer were treated with a CD36 blocking antibody or IgG control antibody, followed by 5% v/v serum from C57BL/6 mice exposed to MWCNT in conjunction with MMP blockade. qPCR performed on cell isolates to access cytokine gene expression changes. Shown are gene expression for a Ccl2, b Il6, c Tgfb, d Icam1, and e Vcam1. p values based on 3-way ANOVA presented for each figure. N = 4–5 per group. Data presented are means ± SEM

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Particle and Fibre Toxicology

ISSN: 1743-8977

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