Fig. 3
From: The mechanism of cell death induced by silver nanoparticles is distinct from silver cations
Presence of Ag+ in AgNP dispersions masks differences in sensitivity of cell lines to AgNPs. Representative dose response curves following 72 h AgNP-Ag+ exposure in the following proportions A 99% AgNP/1% Ag+, B 95% AgNP/5% Ag+, C 90% AgNP/10% Ag+, D 70% AgNP/30% Ag+. Cell viability following AgNP-Ag+ exposure was quantified by MTT assay. E IC50 was determined using GraphPad Prism. Data used to calculate IC50s were obtained from 6 technical replicates per dose and 2–3 independent experiments. Statistical analysis was performed by two-way ANOVA followed by post-hoc Sidaks test. Significant differences are indicated (*p < 0.05; **p < 0.01; ****p < 0.0001)