Fig. 5

Identification and functional relevance of the 41 top-ranked discriminant peptides. a Fold-change response of the identified discriminant peptides grouped by their originating protein symbol (excluding FGA). Mean ± S.E., q-value < 0.05, normalized to the Low group mean. b Functional classification of the 20 parent proteins for the identified discriminant peptides. c Fold-change response for six identified fibrinopeptide A fragments per normal exoproteolytic serum metabolism, with the most stable (15.2 h half-life) shown boxed. Mean ± S.E., q-value < 0.05, normalized to the Low group mean. d Plot of the mean peptide ion intensity across all study subjects (gray) and the half-life in hours (orange, values from Yi et al. [28]) for the six identified fibrinopeptide A fragments