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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

Fig. 4

Histopathological analysis of lung tissue injury and inflammation. Light photomicrographs of centriacinar regions in the lungs of mice exposed to A filtered air B CB, one exposure, C CB, four exposures, D O3, one exposure, E O3, four exposures, F CB + O3, one exposure, and G CB + O3, four exposures. As there was no pathology observed in filtered air single or four exposure groups only single exposure group is presented in the image. Tissue sections were stained with hematoxylin and eosin (H&E) and evaluated by a board-certified veterinary pathologist in a blinded manner. N = 3–4 animals per group. tb = terminal bronchiole, ad = alveolar duct, a = alveolar parenchyma, e = bronchiolar airway epithelium, stippled arrows = alveolar macrophages laden with carbon black, solid arrows = exfoliated epithelial cells, open arrow = alveolar macrophages without particles, solid arrowheads = carbon black particles, open arrowhead = type II epithelial cell hyperplasia

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