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Fig. 5 | Particle and Fibre Toxicology

Fig. 5

From: Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction

Fig. 5

Changes in Nicotinamide Adenine Dinucleotide Phosphate (NADPH) pathway in air, CB, O3, and CB + O3 co-exposed mice. A Real-time PCR analysis of mRNA expression (fold changes) in the lung homogenates B hydrogen peroxide (H2O2) concentration measured by Amplex Red assay in the lung homogenates. For these studies experimental design and exposure concentrations are the same as reported in Fig. 3. Data are presented as the mean ± standard error of the mean (SEM) and analyzed by two-way Analysis of Variance (ANOVA) followed by Turkey’s post hoc test. There were n = 5–7 animals per group and per timepoint were used for these analyses. Where *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001. PCR Analyses (panel A) * denotes significantly different from air/sham, ^ denotes significantly different from O3 at same time point

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