Fig. 6
Transcriptomic changes summarized through KEGG gene ontology. Using PathfindR, KEGG gene ontology was applied to the CB, O3, and CB + O3 groups after A single and B four exposures. C The unique genes identified in the CB + O3 group were further stratified to find only unique gene ontologies between the single and four exposures. The unique pathways for D single and E four exposures are provided. Additional ontology and differential gene expression data is provided in Additional file 1. ID = ID of the enriched term for KEGG ontology, Term Description = description of the enriched term and identified pathway, Fold Enrichment = fold enrichment value for the enriched term (Calculated using ONLY the input genes), Support = the median support (proportion of active subnetworks leading to enrichment within an iteration) over all 10 iterations, Lowest P-Value = the lowest adjusted-p value of the given term over all iterations, CB = 10 mg/m3 CB exposure, O3 = 2 ppm O3 exposure, CB + O3 = 10 mg/m3 CB and 2 ppm O3 inhalation co-exposure