Table 1 The PECO (population, exposure, comparator, outcome)
From: Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review
Variable | Description |
|---|---|
Population | Experimental rodents |
Exposure | Any administered dose of the selected compounds (silica dust (amorphous or crystalline) or asbestos)) as singular compounds |
Comparator | Exposure to vehicle-only or untreated control |
Outcome | Systemic autoimmune diseases: systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, autoimmune myositis Systemic autoimmunity features: kidney pathology/glomerulonephritis, lung pathology, autoantibodies, changes in serum immunoglobulins, changes in serum cytokines, proteinuria, skin involvement, joint involvement |