Table 5 Parameters of exposure protocols used in included studies
From: Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review
Exposure protocol | Â | Â |
|---|---|---|
|  | Asbestos (N = 11) | Silica (N = 23) |
Exposure route | Â | Â |
 Intratracheal instillation | 9 | 1 |
 Intranasal instillation | 0 | 14 |
 Oropharyngeal/transoral instillation | 1 | 7 |
 Intraperitoneal injection | 2 | 0 |
 Subcutaneous injection | 0 | 3 |
Repeated dosing or single dosing | Â | Â |
 Single | 3 | 14 |
 Double | 6 | 3 |
 Repeated (> 2x) | 2 | 8 |