Skip to main content
Fig. 3 | Particle and Fibre Toxicology

Fig. 3

From: Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model

Fig. 3

Localization of CNT/F in relation to the lymphatics and pleura. A Immunofluorescent image of a bronchiole from a mouse 84 d after MW #6 exposure showing staining for e-cadherin (green) and podoplanin (red). Podoplanin was present in lymphatic endothelium, alveolar type 1 cells, and basal cells and allows the demonstration of bronchiolar lymphatics (solid arrows) and a meshwork of podoplanin staining consistent with lymphangiogenesis in the bronchiolar wall (*). MW #6 was present within that meshwork and a few MW extend from the meshwork through the epithelium (dashed arrow). B Photomicrograph of a partially polarized lung section from a mouse 84 d after CNF #1 exposure. CNF were present in alveolar macrophages and two CNF were in the pleura (arrows)

Back to article page