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Fig. 6 | Particle and Fibre Toxicology

Fig. 6

From: Oral administration of TiO2 nanoparticles during early life impacts cardiac and neurobehavioral performance and metabolite profile in an age- and sex-related manner

Fig. 6

OPLS-DA score plots using (R2X, R2Y, and Q2) plasma metabolite differentiating male (A, C, E) and female (B, D, F) pups orally administered TiO2 NP from vehicle control. Rat pups were dosed between PND 2–5 (A, D), PND 7–10 (B, E), or PND 17–20 (C, F) and sacrificed on PND 21. OPLS-DA plots show a clear grouping of metabolites in male pups (A–C). However, for female pups OPLS-DA plots show a clear grouping of metabolites in female pups for PND 2–5 (D), but not for PND 7–10 (E) and PND 17–20 (F)

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