Fig. 6

The survival status of AgNPs-treated mice and the distribution/accumulation kinetics of intraperitoneally injected AgNPs during the 14-day observation period. A The survival rate of BALB/c mice (n = 3–5 per group) receiving treatment with a single IP injection of different doses of SCS (i.e., 1, 4, 6 and 8 mg/kg) and SAS (i.e., 1, 8, 25 and 250 mg/kg), respectively. B Whole-organ IVIS images of lung, kidneys, liver and spleen from mice treated with RBITC-AgNPs (8 mg/kg) for 1, 5, 24 and 48 h. C Quantification of IVIS imaging data. The amount of Ag deposited in spleen (D), liver (E), and kidney (F) of SCS- or SAS- treated mice (2 and 4 mg/kg) (n = 3) was determined by GFAAS on days 0, 2, 7, and 14 post-exposure. Mice of the control group (n = 3) in each experiment was treated with a single IP injection of saline