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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo

Fig. 7

Morphological appearance and histopathology of the major target organs for AgNPs accumulation. A Direct observation of morphological alterations in kidneys, liver, spleen, and pancreas from control and SCS- or SAS-treated mice (SCS: 8 mg/kg; SAS: 8 and 25 mg/kg). The black arrow indicates AgNPs accumulation in pancreas. B H&E-stained of liver sections from untreated control and SCS- or SAS-treated mice (2, 4 and 8 mg/kg; a single IP injection). Mice were sacrificed to obtain liver tissues on the 2nd and 14th day after exposure. C H&E-stained histological sections of pancreas from control and SCS- or SAS-treated mice (8 mg/kg; a single IP injection). Mice were sacrificed to collect pancreatic tissues on the 2nd post-exposure. The red arrow indicates focal necrotic injury in pancreatic tissues of SCS-treated mice

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