Use of an in silico knowledge discovery approach to determine mechanistic studies of silver nanoparticles-induced toxicity from in vitro to in vivo

Table 4 Serum biochemical data of the control and SCS- and SAS-treated mice

Parameters	Reference	Control	SCS (8 mg/kg)	SAS (8 mg/kg)
ALT (UI/L)	53.00 ± 7.88	38.66 ± 15.14	700.00 ± 262.71*	31.33 ± 5.13
AST (UI/L)	122.01 ± 23.70	192.00 ± 9.16	1198.00 ± 510.65*	221.00 ± 86.74
CRE (mg/dL)	0.34 ± 0.08	0.37 ± 0.05	0.33 ± 0.05	0.53 ± 0.11
BUN (mg/dL)	30.07 ± 9.85	16.63 ± 2.57	20.43 ± 1.33	39.90 ± 13.32
GLU (mg/dL)	151.77 ± 58.63	80.66 ± 22.27	123.33 ± 9.07	63.00 ± 4.58
AMYL (UI/L)	500–1500	1357.00 ± 114.50	5410.66 ± 1483.72**	1301.33 ± 383.91

The reference values for each parameter in female BALB/c mice were provided by the Laboratory Animal Center of NCKU. Data are expressed as mean ± standard deviation. *(P < 0.05) and **(P < 0.01) denote significant differences between the control and treatment groups. ALT: Alanine aminotransferase; AST: aspartate aminotransferase; CRE: creatinine; BUN: blood urea nitrogen; GLU: glucose; AMYL: amylase

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