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Fig. 7 | Particle and Fibre Toxicology

Fig. 7

From: Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies

Fig. 7

The crosstalk of Macrophage with Epithelial in response to long-term coal exposure. A The intercellular interactions among different cell types were shown in circos plot, which represents a ligand of one cell type directed to a corresponding receptor of another cell type. The thickness of each string corresponds to the number of receptor-ligand pairs, and color refers to cell type. B The numbers of significant ligand-receptor pairs between epithelial cells and other cells in coal dust-exposed (black bar) and control lung (red bar). C The computational method used to predict the macrophage-epithelial communication based on L-R interaction through scRNA-Seq provides prominent potential signaling in coal dust-exposed (right) and control (left) lungs. D Dot plot showing the mean level and percentage of selected interaction pairs associated with the response of epithelial cells and macrophages (directional). Each gene expression was considered independently for each sample source. E After the Single-cell transcriptome sequencing comparative analysis was performed, a five-set Venn diagram was used to depict unique and shared (overlapping circles) sets of differentially expressed genes (DEGs) in the coal-exposed lungs. Each ellipse shows the total number of coding sequences in one cell type. Intersections indicate predicted shared content

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