Fig. 10
The effects of AhR-inhibition on the cytokine responses induced by combined exposure to DEPB0 and stone particles. HBEC3-KT cells were exposed to the AhR-specific inhibitor CH223191 (10 μM) for 30 min prior to 24 h exposure to 25 μg/mL (2.6 μg/cm2) DEPB0 and 200 μg/mL (21.1 μg/cm2) anorthosite (A), rhomb porphyry (B) and quartz diorite (C). The release of CXCL8 (i) and IL-1β (ii) in the cell culture supernatants was measured using ELISA. Results are presented as boxplots of 5 independent experiments (Box: 25th–75th percentile, whiskers: minimum and maximum values, line: median, +: mean). Statistically significant differences were determined using two-way repeated measures ANOVA followed by Dunnett’s and Å Ãdák's post-tests. All values were log-transformed prior to statical analysis to satisfy model assumptions. *Statistically significant difference from the respective control. #Statistically significant difference between exposure groups