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Fig. 4 | Particle and Fibre Toxicology

Fig. 4

From: Nano-titanium dioxide inhalation exposure during gestation drives redox dysregulation and vascular dysfunction across generations

Fig. 4

Hydrogen peroxide production rate in tissues from F1 males at 8 weeks of age. F1 plasma samples analyzed for A IL-6, B glucose, and C protein carbonyl content. C H2O2 production capacity detected by coumarin boronic acid in liver homogenates with assessment of liver glutathione D reduced GSH, E total GSH, and F GSSH:GSH ratio and G, H western blot detection of catalase and phospho NF-κB. I H2O2 production capacity detected by coumarin boronic acid in aorta homogenates with assessment of liver glutathione J reduced GSH, K total GSH, and L GSSH:GSH ratio and M western blot detection of phospho NF-κB. n = 4–20; *p < 0.05 Sham-control group versus nano-TiO2-exposed groups

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