Fig. 4
β-amyloid protein levels in 5xFAD transgenic mice exposed to different nanomaterials. Aβ40 (A, D) and Aβ42 (B, E) protein levels and Aβ42/Aβ40 ratio (C, F) were determined by ELISA in cortex brain homogenates of 5xFAD mice after oral exposure to SiO2 and CeO2 nanomaterials [0.1% and 1%] for 3 weeks (A–C) or 14 weeks (D–F). Statistical analysis was performed using ANOVA with Dunnett post-hoc analysis; *p < 0.01 versus mice exposed to control feed pellets. N = 6 animals per group for 3 weeks study and N = 7 for 14 weeks study