Fig. 7

Study design. Nine weeks old female C57BL/6J or 5xFAD mice were fed ad libitum for 3 weeks (A) or 14 weeks (B) with feed pellets loaded with 0.1% or 1% (w/w) CeO₂ or SiO₂ nanomaterials (NMs) or control feed pellets. Motor function, memory and anxiety were determined in a series of behaviour tests performed in the weeks before the necropsies, as follows for the respective substudies: The X-maze test (XM) was performed on exposure day 19 (A) or 95 (B), the string test (ST) was performed on day 20 (A) or 88 (B), the open field test (OP) was performed on day 91 (B) and the balance beam test (BM) was performed on day 96 (B). Aβ plaque formation and Aβ ELISA (A, B) or markers of neuroinflammation and oxidative stress (B) were analysed in the brains of the mice after necropsy