Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice

Table 2 Lengths and weight/length ratios of colon and small intestine

	Control		SiO₂ [0.1%]		SiO₂ [1%]		CeO₂ [0.1%]		CeO₂ [1%]
	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD	C57BL/6J	5xFAD
A
Colon length (cm)	7.88 ± 0.66	7.77 ± 0.60	7.23 ± 0.65	7.41 ± 0.68	7.81 ± 0.53	6.97* ± 0.54	7.58 ± 0.56	8.00 ± 0.54	6.97 ± 0.89	7.56 ± 0.68
C. weight/length ratio (g cm⁻¹)	0.022 ± 0.002	0.021 ± 0.003	0.022 ± 0.002	0.021 ± 0.004	0.020 ± 0.003	0.023 ± 0.003	0.022 ± 0.003	0.022 ± 0.003	0.022 ± 0.003	0.022 ± 0.003
Small intestine length (cm)	31.30 ± 2.47	34.20 ± 2.55	31.48 ± 1.68	33.00 ± 2.66	32.34 ± 2.13	32.11 ± 2.52	31.95 ± 3.05	32.66 ± 2.83	31.55 ± 1.99	31.64 ± 2.43
S.I. weight/length ratio (g cm⁻¹)	0.028 ± 0.005	0.024 ± 0.005	0.025 ± 0.004	0.026 ± 0.003	0.024 ± 0.004	0.024 ± 0.008	0.024 ± 0.003	0.026 ± 0.003	0.028 ± 0.002	0.028 ± 0.003
B
Colon length (cm)	8.60 ± 0.85	8.16 ± 0.73	8.32 ± 0.65	8.36 ± 0.55	8.55 ± 0.27	8.16 ± 0.62	8.55 ± 0.43	8.19 ± 0.85	7.80 ± 0.76	8.00 ± 0.51
C. weight/length ratio (g cm⁻¹)	0.021 ± 0.004	0.023 ± 0.003	0.022 ± 0.003	0.022 ± 0.002	0.024 ± 0.002	0.022 ± 0.002	0.023 ± 0.003	0.024 ± 0.004	0.025 ± 0.003	0.024 ± 0.003
Small intestine length (cm)	31.88 ± 2.65	31.19 ± 3.08	34.77 ± 1.53	31.79 ± 3.51	31.50 ± 3.12	32.27 ± 1.61	32.47 ± 1.83	33.55 ± 1.36	30.68 ± 1.64	32.22 ± 1.39
S.I. weight/length ratio (g cm⁻¹)	0.025 ± 0.003	0.027 ± 0.004	0.025 ± 0.001	0.027 ± 0.003	0.025 ± 0.003	0.025 ± 0.002	0.026 ± 0.003	0.025 ± 0.004	0.026 ± 0.003	0.025 ± 0.003

Data represent mean ± standard deviation of C57BL/6J and 5xFAD mice colon and small intestine length after 3 weeks (A) or 14 weeks (B) exposure to CeO₂ or SiO₂ [0.1% or 1%] in feed pellets ad libitum versus the body and organ weights of the corresponding mice that received control feed pellets. C = Colon; S.I. = Small intestine. Statistical analysis was performed using ANOVA followed by Dunnett evaluation
*p < 0.05 versus 5xFAD mice exposed control feed pellets

ISSN: 1743-8977