Table 3 Liver and spleen, small and large intestine histopathology

Liver

n = 5

n = 6

n = 6

n = 6

n = 6

 Focal inflammatory infiltrates

1 (5)

1 (4), 2(2)

1 (6)

1 (6)

1 (6)

 Focal necrosis

1 (2)

1 (1)

1 (2)

0 (6)

0 (6)

 Increased interstitial cells

0 (5)

2 (1)

1 (1)

1 (1)

1 (1)

 Increased glycogen

0 (5)

0 (6)

0 (6)

2 (2), 3 (1)

0 (6)

 Vacuolation

0 (5)

0 (6)

0 (6)

0 (6)

2 (3)

Spleen

n = 5

n = 6

n = 6

n = 5*

n = 6

 Increased pigment

2 (1)

2 (3)

0 (6)

2 (2)

1 (1), 2 (1)

 Congestion

0 (5)

2 (1)

0 (6)

0 (5)

0 (6)

 Increased extramedullary hematopoiesis

0 (5)

0 (6)

3 (1)

1 (1)

2 (1)

 Increased megakaryocytes

0 (5)

0 (6)

2 (1)

0 (5)

0 (6)

*One sample not evaluable due to embedding artefacts

Small and large intestine

Minimal focal inflammatory infiltrates (intra-mucosal) in all specimens

In some cases, inflammatory infiltrates in adjacent tissue and pancreas with focal vacuolation (grade 2)

Clearly visible goblet cells in PAS stained slides (small intestine + ; large intestine +++)

Partly mucus on surface. Gut associated lymphoid tissue (GALT) in almost all specimens detectable