Fig. 6From: Ultrasmall iron oxide nanoparticles cause significant toxicity by specifically inducing acute oxidative stress to multiple organsDetection of ·OH in vivo. The concentration of ·OH in serum (a), heart (b), liver (c), spleen (d), lung (e) and kidney (f) after intravenous injection of different-sized Fe3O4, SiO2 and Au NPs (100 mg/kg) for 2 h and 3-CCA for another 1 h. The ROS was determined using 3-CCA as an indicator. All of the data were presented as the mean ± SD (n = 3). P values: *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the corresponding control groupBack to article page